SAT Reading & Writing · Form, Structure, and Sense

By the time researchers sequenced the tumor's genome, the cancer ______ resistant to three separate rounds of chemotherapy.

By the time researchers sequenced the tumor's genome, the cancer ______ resistant to three separate rounds of chemotherapy.

Which choice completes the text so that it conforms to the conventions of Standard English?

Answer and explanation

Answer: C: had become

Two past events occur in sequence: the cancer becoming resistant happened first, across three treatment rounds, and the genome sequencing happened afterward, revealing what had already occurred. That earlier-past-before-a-later-past relationship calls for the past perfect, had become. Becomes is present tense and breaks the past-tense narrative. Became would place both events at the same rough time, losing the sequence. Will become shifts to future tense, inconsistent with a story told entirely in the past.

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