SAT Reading & Writing · Rhetorical Synthesis
A student has researched CAR-T cell therapy and compiled the following notes: - CAR-T therapy involves modifying a patient's own T cells…
A student has researched CAR-T cell therapy and compiled the following notes:
- CAR-T therapy involves modifying a patient's own T cells to recognize specific proteins on tumor cells.
- CD19-directed CAR-T therapy can induce remission in some patients with treatment-resistant B-cell cancers.
- Cytokine release syndrome is a major acute side effect of the treatment.
- Neurotoxicity can also occur as a side effect.
- Tumors can relapse after losing or reducing the specific target protein the therapy was designed to recognize.
- Manufacturing CAR-T cells is currently an individualized process for many available treatments.
The student wants to present a balanced view of CAR-T therapy that includes both its promise and its limitations. Which choice most effectively uses relevant information from the notes to accomplish this goal?
- CAR-T therapy involves modifying a patient's own T cells to recognize specific proteins on tumor cells.
- CD19-directed CAR-T therapy can induce remission in some patients with treatment-resistant B-cell cancers.
- Cytokine release syndrome is a major acute side effect of the treatment.
- Neurotoxicity can also occur as a side effect.
- Tumors can relapse after losing or reducing the specific target protein the therapy was designed to recognize.
- Manufacturing CAR-T cells is currently an individualized process for many available treatments.
The student wants to present a balanced view of CAR-T therapy that includes both its promise and its limitations. Which choice most effectively uses relevant information from the notes to accomplish this goal?
Answer and explanation
Answer: C: While CD19-directed CAR-T therapy can induce remission in some patients with treatment-resistant B-cell cancers, tumors can also relapse after losing or reducing the specific target protein the…
"Balanced view" requires naming both a genuine strength and a genuine limitation together. C does exactly that, pairing the therapy's real success (remission in resistant cancers) with a real limitation on that success (antigen-loss relapse). A describes the mechanism neutrally, without promise or limitation. B names a practical limitation alone. D names side effects alone, without any counterbalancing mention of the therapy's benefits.
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